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   evaluation of albizia lebbeck and curcuma longa extracts on gastrointestinal motility, safety, and hematological parameters: a sub-chronic toxicity and pharmacological study  
   
نویسنده fagbohun bushirat oyenike ,adewuyi hassan abdulsalam ,musa maryam ,unuata ojochenemi nora ,ogar ochonung emmanuel ,achi agor emmanuel ,mohammed usman abiola ,olukayode jaiyeola tolulope
منبع asia pacific journal of medical toxicology - 2025 - دوره : 14 - شماره : 1 - صفحه:1 -6
چکیده    Background: gastrointestinal disorders are prevalent worldwide, necessitating effective and safe therapeutic options. the use of herbal medicine dates back thousands of years, with various cultures employing plants to treat ailments. albizia lebbeck and curcuma longa extracts have traditional uses in managing gastrointestinal issues.methods: this study evaluated the effects of albizia lebbeck and curcuma longa extracts on gastrointestinal motility, safety, and hematological parameters in rats. the study was done at federal university of technology minna, in september 2024, minna niger, state nigeria. gastrointestinal motility was assessed using gastric emptying rate and intestinal transit time. safety was evaluated through sub-chronic toxicity studies, including liver and kidney function tests and hematology parameters.results: albizia lebbeck and curcuma longa extracts significantly enhanced gastrointestinal motility and antioxidant activity (p<0.05), improved liver function (alt: -15.4 %, ast: -12.5 %), and kidney function (creatinine: -10.3 %, urea: -9.5 %). hematology parameters showed significant increases in hemoglobin (+8.5 %) and lymphocyte percentage (+11.9 %). no significant toxicity was observed in bodyweight, hematology, biochemistry or organ weight.conclusion: results of this study demonstrate the prokinetic effects of albizia lebbeck and curcuma longa extracts on gastrointestinal motility in rats. the active ingredients of these herbal extracts may contribute to their prokinetic effects by modulating gut motility and secretion. the combination therapy potentiated the prokinetic effects, suggesting a synergistic interaction between the two herbal extracts. these findings support the traditional use of these herbal remedies in managing gastrointestinal disorders, with a favorable safety profile. further studies are needed to elucidate the exact mechanisms underlying these effects and to confirm their safety and efficacy in human clinical trials.
کلیدواژه albizia lebbeck ,curcuma longa ,gastrointestinal motility ,sub-chronic toxicity ,safety
آدرس ogun state college of science and technology, department of pharmacy technician, nigeria, federal university of technology minna, department of biochemistry, nigeria, kogi state polytechnic, department of biochemistry, nigeria, federal university of technology minna, department of biochemistry, nigeria, university of benin, department of biochemistry, nigeria, university of cross river, department of chemistry and biochemistry, calaber, nigeria, ahman pategi university, department of biological sciences, nigeria, crawford university igbesa, department of biochenistry and molecular biology, nigeria
پست الکترونیکی tolulope.jaiyeola@crawforduniversity.edu.ng
 
     
   
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