EDITORIAL: Use of Chemical Warfare Agents in Ancient History: the case of Persians and Romans in Dura Europos, Modern Syria in 256 C.E.

Background: chemical warfare agents (cwa) were most notably used during the first world war in europe, against iranians andkurdish citizens of iraq at the hands of saddam hossein’s regime in 1980s and more recently in syria. the use of cwa is bannedunder the international law.methods: ancient uses of cwa are not well studied. recently, their use during the persian siege of the roman-held dura-europos(salihiyah) in modern syria in 256 c.e. has been theorized by revisiting the archaeological findings from dura-europos from the1930s.case study: the paper describes the history of persia (iran) and rome in that era and particularly shapur i, the second king (shah) ofthe [sasanian] persian empire (215 - 270 c.e.) and valerian, publius licinius valerianus augustus, the roman emperor (193/200 -264 c.e.). in addition, composition of the potentially applied cwa and clinical findings related to the exposure are postulated througha medical toxicology lens taking into account archeological evidence (carbonized top of the tunnels and bodies and yellow crystalsfound in the tunnel), recent research and contemporary historical notes.conclusion: it is plausible that a combination of fire accelerant or so called pitch (oil based substance, naphtha, bitumen or crude oil)and sulphur dioxide (so2) were used in this occasion. so2 in combination with water on the body membranes creates highly toxicsulphurous acid (h2so3) which is life threatening in a small enclosed space. as a result, a burning sensation in the nasopharynx andeyes, coughing, dyspnea, choking that led to pulmonary edema and death would have shortly followed. severe clinical manifestations,panic and consequent mass hysteria of the toxic exposure should have prevented any organized retreat. in this incident, nineteenroman and one persian soldier were killed.