hepatic failure in a young woman following ingestion of tribulus terrestris

Background: plants have been used for the treatment of a wide range of conditions since ancient times but some have side effects and toxic effects that limit their use. tribulus terrestris is traditionally used for lowering blood pressure, inhibiting kidney stone formation and inducing weight loss. in this case study, we present an iranian woman who suffered from liver failure after using this plant. case presentation: a 31-year-old iranian woman was admitted to emamreza hospital due to epigastric pain radiating to back and shoulders, and  weakness, malas,neusia and icterus. upon admission,, her vital signs were normal. she had been consuming tribulus terrestris as an herbal tea , several times a day for 2-3 months, in order to lose weight. upon physical examination, the patient had generalized icterus and laboratory tests showed elevated transaminases, pt, and inr. various causes of hepatic failure, such as viral hepatitis and autoimmune hepatitis, were ruled out and the only probable diagnosis was toxininduced liver failure. conclusion: herbal plants may have some beneficial medical effects but they can also cause toxicity. consistent use and high dose of tribulus terrestris may cause hepatic failure and death.