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Evaluation of Oxidative Stress in Combination Therapy with D-penicillamine and N-Acetylcysteine (NAC) in Lead Poisoning in Opium Addicts
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نویسنده
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shojaeepour saeedeh ,fazeli mehdi ,mandegary ali ,sayed-mirzaei mehdi ,ahmadi nahid ,saeedi arastoo ,oghabian zohreh
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منبع
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asia pacific journal of medical toxicology - 2017 - دوره : 6 - شماره : 4 - صفحه:123 -128
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چکیده
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Background: n-acetylcysteine (nac) is a putative antioxidant and has gained attention as a promising agent for chelating heavy metals including lead. considering the animal studies results, we hypothesized that adding nac to the treatment regimen may improve the success of treatment with lead chelators. method: a total of 46 patients who were lead-poisoned opioid addicts were divided into two groups randomly and treated with d-penicillamine (dp, 1g/day in four equal divided doses) and nac+dp (1 g/day + 150 mg/kg/day). the efficacy of treatment was evaluated by hospitalization period. meanwhile, the oxidative stress parameters including lipid peroxidation, protein carbonyl, total antioxidant capacity (tac), glutathione concentration and super oxide dismutase (sod) activity were determined on admission and discharge and compared with healthy normal controls. results: hospitalization period was not different between the two groups. treatment with dp and dp+nac significantly decreased oxidative stress in patients. on the discharge day, the sod activity and tac were significantly higher in dp+nac group in comparison with the dp group. conclusion: although nac recovers antioxidant capacity, the advantages of nac in improvement of dp efficacy in lead poisoning is questionable. further studies with larger sample size and combination with other chelators are recommended
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کلیدواژه
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D-penicillamine; Lead poisoning; N-acetyl cysteine; Opium addicts
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آدرس
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shiraz university, faculty of veterinary medicine, department of pharmacology & toxicology, Iran. kerman university of medical sciences, pharmaceutics research center, institute of neuropharmacology, Iran, shiraz university, faculty of veterinary medicine, department of pharmacology & toxicology, Iran, kerman university of medical sciences, pharmaceutics research center, institute of neuropharmacology, school of pharmacy, neuroscience research center, department of toxicology & pharmacology, Iran, kerman university of medical sciences, gastroenterology and hepatology research center, institute of basic and clinical physiology sciences, departmrnt of internal medicine, iran, kerman university of medical sciences, school of pharmacy, department of toxicology & pharmacology, Iran, fars nioc health organization, Iran, kerman university of medical sciences, school of pharmacy, gastroenterology and hepatology research center, institute of basic and clinical physiology sciences, department of toxicology & pharmacology, iran
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Authors
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