Toxicological Screening of Drug Facilitated Crime among Travelers in Dhaka, Bangladesh

Introduction: drug-facilitated robberies, primarily of public transport passengers, are a massively increasing public health emergency and law enforcement challenge in dhaka, the capital city of bangladesh. methods: we conducted a prospective clinical and toxicological study of 38 patients with acute poisoning who had been admitted to dhaka medical college hospital between october 2008 and december 2008 and suspected to be victims of drug-facilitated crimes. blood samples were obtained on admission and one hour later to identify changing concentrations of the drugs used by the perpetrators. toxicological screening was performed by lc-tof/ms and lc-ms/ms analysis of the blood samples of 22 of these patients. results: all of the patients in our series were male, 17-60 years of age, and none had any memory of the time between the ingestion of the drug and the onset of unconsciousness. all had lost the valuables they had been carrying at the time of the incident. on admission, 50% of the patients had a glasgow coma score (gcs) of 5-10. most of them were poisoned while travelling (79%), most frequently by bus (70%). they had been offered tea (21%), other drinks (26%), prickles (18%), herbal medicines (10%) or cigarettes (5%) by the suspected perpetrators. screening by lc-tof/ms and lc-ms/ms revealed pharmacologically active concentrations of lorazepam in the blood samples of all 22 cases (191±138 μg/l, mean±sd); midazolam in 12 (149±99 μg/l); diazepam in 3 (217±144 μg/l) and nordiazepam in 6 cases (364±186 μg/l). in five cases the lorazepam concentration of the second blood sample was at least 15% higher than in the sample drawn on admission one hour earlier, indicating continuing absorption. this suggests that only these five patients had been admitted within the 1-2 hour long absorption phase. almost all of the patients left the hospital unnoticed after clearing up, two likely prematurely within 12 hours of admission, and no mortality was observed. conclusions: this study reveals flexibility of the criminals in dhaka in using different mixtures of benzodiazepines to incapacitate and then rob their victims.the findings of our study have important implications for the clinical management of drug-facilitated crime victims. in particular, they highlight an urgent need to widely deploy rapid diagnostic and analytical forensic and clinical toxicology facilities in bangladesh, introduce and implement modifications to emergency department protocols, and provide post-recovery psychological support for victims who often suffer existentially threatening economic losses in addition to the poisoning.