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Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion
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نویسنده
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Rahmati Batool ,Khalili Mohsen ,Hamoleh-Shalali Zohreh ,Roghani Mehrdad ,Baluchnejadmojarad Tourandokht
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منبع
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journal of basic and clinical pathophysiology - 2015 - دوره : 3 - شماره : 2 - صفحه:25 -28
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چکیده
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Background and objective: parkinson's disease (pd) is a movement disorder with debilitating symptoms. available treatments for pd mainly include its symptomatic relief with no prevention of its progression. due to the iron-chelating and antioxidant effect of phytic acid (pa), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of pd in rat. materials and methods: unilateral intrastriatal 6-ohda-lesioned rats were daily pretreated with pa p.o. at a dose of 100 mg/kg for three days till 1 h pre-surgery. apomorphine-induced rotations were counted at 1st week post-surgery.results: a significant contralateral rotational behavior was observed in 6-ohda-lesioned rats (p < 0.0005) and pa pretreatment significantly reduced it (p < 0.05).conclusion: these findings imply that pre-lesion pa treatment could attenuate motor asymmetry in experimental model of pd and this may be of benefit in lessening motor derangements in afflicted patients.
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کلیدواژه
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Phytic acid ,Parkinson’s disease ,6-hydroxydopamine ,Motor asymmetry
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آدرس
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shahed university, Neurophysiology Research Center, Shahed University, Tehran, Iran, ایران, shahed university, Neurophysiology Research Center, Shahed University, Tehran, Iran, ایران, shahed university, School of Medicine, Shahed University, Tehran, Iran, ایران, shahed university, Neurophysiology Research Center, Shahed University, Tehran, Iran, ایران, iran university of medical sciences, Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, ایران
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Authors
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