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   Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation  
   
نویسنده Narenjkar Jamshid ,Abyar Zeinab ,Roghani Mehrdad
منبع journal of basic and clinical pathophysiology - 2015 - دوره : 3 - شماره : 2 - صفحه:13 -18
چکیده    Background and objective: hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. this study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (stz)-diabetic rats using formalin, hot tail immersion, and paw pressure tests.materials and methods: this study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. the treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. finally, hyperalgesia were assessed using standard tests. meanwhile, serum mda and tnf? level was also measured.results: curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p < 0.05), increased tail flick latency (p < 0.05) and vocalization score (p < 0.05) as compared to diabetic group. curcumin treatment also decreased serum level of mda (p < 0.05) and tnf? (p < 0.05). conclusion: chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes.
کلیدواژه Curcumin ,Diabetes mellitus ,Anti-nociceptive ,Formalin test ,Hot tail immersion test ,Paw pressure test ,Lipid peroxidation ,Inflammation
آدرس shahed university, Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran, ایران, shahed university, School of Medicine, Shahed University, Tehran, Iran, ایران, shahed university, Neurophysiology Research Center, Shahed University, Tehran, Iran, ایران
پست الکترونیکی mehjour@yahoo.com
 
     
   
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