antiepileptic effect of nobiletin in ptz-induced catamenial seizures in the rat

Background and objective: catamenial epilepsy is a seizure pattern associated with the menstrual cycle that happens in specific women with epilepsy while menstruating. nobiletin is a type of polymethoxy flavonoid and with many beneficial physiological effects. this study aimed to determine antiepileptic effect of nobiletin in ptz-induced catamenial seizures in rats.materials and methods: thirty female wistar rats, separated into 5 experimental groups based on their estrus cycle stage (proestrus, estrus, metestrus, diestrus). in the control group, rats received saline, while in experiment 2, the animals were given vpa (75 mg/kg). during experiments 3-5, animals received nobiletin at doses 12.5, 25, and 50 mg/kg, respectively. then, the animals received an 80 mg per kilogram intraperitoneal injection of ptz (80 mg/kg). following the start of the seizure, the animals’ actions were observed for a period of 30 minutes to evaluate the onset of itms and itts. experiments were conducted between 9 a.m. and 12 p.m. to minimize the influence of circadian rhythm on vulnerability to seizures.results: based on findings, nobiletin (20 and 30 mg/kg) increased the initiation time myoclonic seizures (itms) and initiation time of tonic-clonic seizures (itts) and decreased seizure duration (sd) after ptz administration in rats during different stages of the estrous cycle (p<0.05). the effects of nobiletin were more pronounced during metestrus and diestrus in comparison to proestrus and estrus (p<0.05).conclusion: findings suggested that nobiletin has antiepileptic effect in ptz-induced catamenial seizure in rat.