s-allyl cysteine, a bioactive ingredient of allium sativum, alleviates carbon tetrachloride-induced acute renal dysfunction in the mouse

Background and objective: kidney diseases are endangering conditions to public health. carbon tetrachloride (ccl4)-induced model of acute kidney injury (aki) is a reliable model for studying renal damage under different conditions. s-allyl cysteine (sac) is a natural organosulfur compound in aged garlic extract with multiple protective effects. in this study, possible preventive effect of sac in ccl4 model of aki was investigated.materials and methods: for induction of aki, ccl4 (10 ml/kg body weight; 0.175% in olive oil) was intraperitoneally injected and sac was given orally at doses of 25 or 100 mg/kg. functional markers of kidney were determined besides renal analysis of oxidative stress and inflammatory indices.results: sac pretreatment at a dose of 100 mg/kg for 1 week before ccl4 challenge significantly and markedly reduced level of blood urea nitrogen (bun), malondialdehyde (mda), reactive oxygen species (ros), tumor necrosis factor-α (tnf-α), interleukin 6 (il-6), and significantly enhanced superoxide dismutase (sod) activity and with no significant effect on creatinine and catalase activity. in addition, such valuable effects were not observed for sac at a dose of 25 mg/kg in ccl4-exposed group.conclusion: findings of this study indicated beneficial effect of sac subsequent to ccl4-induced kidney injury that is partly mediated through its regulation of oxidative and inflammatory events and upregulating some of the antioxidants.