the effect of royal jelly and endurance exercise on cognitive function and pathological changes of hippocampus tissue in rats with experimental autoimmune encephalomyelitis

Introduction: although the positive effects of physical trainings as well as nutrition on cognitive function are reported, but there is limited information regarding their combined effect. present study aimed to review the effect of royal jelly (rj) and endurance exercise (ee) on cognitive function and pathological changes of hippocampus tissue in rats with experimental autoimmune encephalomyelitis (eae). methods: forty- nine sprague- dawley female eae rats were selected as sample and were assigned to 1) ee+rj100, 2) ee+rj50, 3) ee, 4) rj100, 5) rj50, 6) sham (sh), and 7) eae groups, also 7 healthy rats were assigned to healthy control group (hc). rats in ee groups were trained 4 sessions per week (30 minutes with speed of 11-15 m/min) for five weeks and rj was injected intra- peritoneally. one-way anova along with tukey’s post hoc were used for data analysis (p≤0.05). results: the percentage of healthy cells in the c1 region (phc), avoidance (am) and spatial memory (sm) levels in the ee group were more favorable than the eae group (p≤0.05). also, the phc in the c3 and c1 regions, the am and sm values in the rj50 and rj100 groups were higher than those of the eae group (p≤0.05). similarly, am and sm levels in the ee+rj50 and ee+rj100 groups were significantly more favorable than the eae group (p≤0.05). the effects of ee+rj50 and ee+rj100 on improving sm and some subsections of am were more favorable than the effects of rj100 (p≤0.05). conclusion: ee and rj (50 and 100mg/kg), alone and in combination, have favorable effects on improving memory and neurogenesis.