interactive effects of swimming training and cinnamon supplementation on changing cardiac mir-133a and mir-21 in the streptozotocin-induced diabetic rats

Introduction: this study aimed to review the synergistic effects of swimming training (st) and cinnamon supplementation (cin) on changing cardiac mir-133a and mir-21 in streptozotocin-induced diabetic rats. methods: a total of 32 diabetic rats were selected as 1) st+ cin, 2) cin, 3) st and 4) diabetic control (dc) groups, and eight healthy rats were selected as the hc group. groups 1 and 3 swam three sessions per week and 2-22 minutes each session for eight weeks. groups 1 and 2 received 200mg/kg/day of aqueous cin extract. qreal time pcr method was used to measure the mir-21 and mir-133a gene expression in heart tissue. results: mir-133a and mir-21 gene expression in cin, st, and st+cin groups increased compared to the dc group (p=0.001), and mir-133a gene expression in the st+cin group enhanced compared to cin and st groups (p=0.001). mir-21 gene expression in st and st+cin groups increased compared to the cin group. in addition, mir-21 gene expression in the st+cin group raised compared to the st group (p=0.001). conclusion: although exercises lead to cardiac adaptations by creating oxidative stress, cinnamon can increase mir-133a as a cardio-protective agent and modulate mir-21 as a marker of cardiac damage. therefore, cinnamon should be used along with exercises in cases of diabetes and heart disease.