short-term effect of aerobic exercise and high-fat diet and consumption of curcumin extract on leptin gene expression in liver tissue in male rats

Introduction: leptin is a protein hormone with a spiral structure similar to cytokines, which is mainly synthesized and released by subcutaneous fat cells in a steady pulsating manner with a peak secretion near midnight. the aim of this study was to compare the short-term effects of aerobic exercise and high-fat diet and curcumin extract on leptin gene expression in the liver tissue of male rats.methods: fifty male rat with two-month-old were prepared and divided into five groups: control (g1), high-fat diet (g2), curcumin and high-fat diet (g3), exercise and high-fat diet (g4), curcumin+exercise+high-fat diet (g5). data analysis was compared using one-way analysis of variance. bonferroni's post hoc test was used to accurately determine the differences between groups. the mean of intra-group differences was also compared using the t-test of the sample.results: the results showed a significant difference in the average leptin gene expression of subjects among 5 groups. the results of bonferroni's post hoc test also showed an increase in the high-fat diet group compared to the control group(p=0.0001), and a decrease in the high-fat diet + curcumin group(p=0.0001), the high-fat diet + exercise group(p=0.0001), and the high-fat diet + exercise + curcumin group compared to the control group(p=0.0001).conclusion: leptin gene is expressed under the influence of short-term exercises and the consumption of curcumin, which is an antioxidant. so that the use of each agent alone causes a decrease or increase in the leptin gene expression in the liver, and the simultaneous use of both factors causes a decrease in the leptin gene expression of these cells in the muscle tissue.