the effects of endurance training and purslane (portulaca oleracea) seed consumption on cytochrome-c and malondialdehyde in the heart tissues of rats poisoned with h2o2

Introduction: oxygenated water intake could increase cell death markers through increasing the free radicals. however, sport activities and antioxidant substances may prevent some of the symptoms caused by free radical production. the present study aimed to investigate the effects of endurance training (et) and purslane (portulaca oleracea; po) seed consumption on cytochrome-c and malondialdehyde (mda) in the heart tissues of rats poisoned with h2o2. methods: in total, 45 male rats were randomly divided into nine groups of five, including control, 50 mg/kg of po, 200 mg/kg of po, 400 mg/kg of po, et, et with 50 mg/kg of po, et with 200 mg/kg of po, et with 400 mg/kg of po, and healthy control. during eight weeks, groups 1-8 received h2o2 (1 mmol/kg) intraperitoneally three times per week, and groups 5-8 ran on treadmill three days per week. results: et and po significantly reduced cytochrome-c and mda (p=0.001), while the interactive effects of et and po on the reduction of cytochrome-c (p=0.52) and mda (p=0.08) were not considered significant. in addition, the administration of 200 mg/kg (p=0.01) and 400 mg/kg of po (p=0.001) significantly decreased cytochrome-c, while 400 mg/kg of po had more significant effects on the reduction of cytochrome-c compared to 200 mg/kg of the substance (p=0.01). moreover, 400 mg/kg of po significantly reduced mda (p=0.001). conclusion: according to the results, et and po could improve cytochrome-c and mda in the heart tissues of the rats poisoned with h2o2.