comparative efficacy of combined oral contraceptive capsules and vitamin d–combined oral contraceptive capsules on ovulatory dysfunction: a randomized clinical trial

Background: food intake and metabolism might play central roles in causing and treating menstrual disorders. vitamin d may lead to the improvement of folliculogenesis through anti-mullerian hormone (amh). this study aimed to compare the effect of vitamin d intake with that of the combined oral contraceptive (coc) capsules on ovulatory dysfunction.methods: this study was conducted on 60 eligible women referred to kowsar qazvin hospital with a complaint of abnormal uterine bleeding (aub). they had a history of excessive, long, and irregular bleeding. the participants in the control and intervention groups received 1 oral ld capsule and a combination of vitamin d and ld capsules on a daily basis for 3 months, respectively. the menstrual bleeding volume, the number of menstrual days, and the menstrual cycle length were evaluated before, during, and after the intervention. the mann-whitney u test, friedman test, independent t test, and cochran q test were used in spss version 24 for data analysis. p values less than 0.05 were considered statistically significant.results: the menstrual bleeding intensity decreased significantly in the intervention group (vitamin d–ld capsule; p = 0.001). over time, both intervention and control groups showed a significant improvement in the number of menstrual days and menstrual cycle length, resulting in a more normal menstrual cycle. however, these 2 parameters remained more natural in the intervention group, a finding which did not indicate any significant differences.conclusion: vitamin d can be used along with ld capsules as a supplementary treatment to lessen menstrual bleeding intensity.