SEVERE HYPERBILIRUBINEMIA DURING FAMILYAL MEDITERRANEAN FEVER ATTACK IN PATIENTS WITH GILBERT'S SYNDROME

Familial mediterranean fever (fmf) is an autosomal recessive disorder characterized by fever and accompanying attacks of serositis. cytokines such as il- 6, tnf-α, il-1β are known to play an active role in fmf pathogenesis. gilbert's syndrome, is a clinical condition that results indirect hyperbilirubinemia during febrile illness, surgery, vomiting and prolonged fasting period because of inhibition of udp-glucuronide transferase activity. increased bilirubin levels during fmf attack is caused suppression of udp-glucuronide transferase activity by cytokines involved in the pathogenesis of fmf. here, we report a patient who had serious indirect bilirubin elevation during an attack of fmf.