ACUTE RENAL FAILURE ASSOCIATED WITH RHABDOMYOLYSIS DUE TO FIBRATE USE

Sixty two years old female patient presented to our emergency service with diffuse, muscle pain, nausea and vomiting. her laboratory investigations showed that urea, creatinine, ast, alt, creatine kinase and phosphorus were increased. the patient was admilted with the diagnosis of acute renal failure. the patient whose history included diabetes mellitus (dm) type 2 and hypertension has received fenofibrate 200 mg daily for hypertrigliceridemia for two months. last ten days she has had too much muscle pain. on the basis of the clinical and laboratory examinations, a diagnosis of acute renal failure secondary to fenofibrate-induced rhabdomyolysis was made. fenofibrate was stopped. intravenous fluid replacement and bicarbonate therapy were started. hemodialysis was not needed. she was discharged after the clinical and laboratory findings returned to normal.