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feasibility of high-dose iodine-131-metaiodobenzylguanidine therapy for high-risk neuroblastoma preceding myeloablative chemotherapy and hematopoietic stem cell transplantation: a study protocol
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نویسنده
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araki raita ,nishimura ryosei ,inaki anri ,wakabayashi hiroshi ,imai yasuhito ,kuribayashi yoshikazu ,yoshimura kenichi ,murayama toshinori ,kinuya seigo
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منبع
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asia oceania journal of nuclear medicine and biology - 2018 - دوره : 6 - شماره : 2 - صفحه:161 -166
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چکیده
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Objective(s): high-risk neuroblastoma is a childhood cancer with poor prognosis despite modern multimodality therapy. internal radiotherapy using 131i-metaiodobenzylguanidine (mibg) is effective for treating the disease even if it is resistant to chemotherapy. the aim of this study is to evaluate the safety and efficacy of 131i-mibg radiotherapy combined with myeloablative high-dose chemotherapy and hematopoietic stem cell transplantation. methods: patients with high-risk neuroblastoma will be enrolled in this study. a total of 8 patients will be registered. patients will receive 666 mbq/kg of 131i-mibg and after safety evaluation will undergo high-dose chemotherapy and hematopoietic stem cell transplantation. autologous and allogeneic stem cell sources will be accepted. after engraftment or 28 days after hematopoietic stem cell transplantation, the safety and response will be evaluated. conclusion: this is the first prospective study of 131i-mibg with high-dose chemotherapy and hematopoietic stem cell transplantation in japan. the results will be the basis of a future nationwide clinical trial.
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کلیدواژه
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131i-mibg ,neuroblastoma ,hematopoietic stem cell transplantation ,prospective study protocol
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آدرس
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kanazawa university, institute of medical, pharmaceutical and health sciences, school of medicine, department of pediatrics, japan, kanazawa university, school of medicine, institute of medical, pharmaceutical and health sciences, department of pediatrics, japan, kanazawa university, school of medicine, institute of medical, pharmaceutical and health sciences, department of nuclear medicine, japan, kanazawa university, school of medicine, institute of medical, pharmaceutical and health sciences, department of nuclear medicine, japan, kanazawa university, innovative clinical research center, japan, kanazawa university, innovative clinical research center, japan, kanazawa university, innovative clinical research center, japan, kanazawa university, innovative clinical research center, japan, kanazawa university, school of medicine, institute of medical, pharmaceutical and health sciences, department of nuclear medicine, japan
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Authors
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