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comparison of the anti-fungal effect of electro- spinning drug-loaded nano-fibers and pad dry drug-loaded fabrics
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نویسنده
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afrashi mehran ,semnani dariush ,alihosseini farzaneh ,dehghan parvin ,maheronnaghsh mehrnoush
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منبع
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journal of textiles and polymers - 2020 - دوره : 8 - شماره : 1 - صفحه:37 -42
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چکیده
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In this research, the anti-fungal effect of fluconazole- loaded polyvinyl alcohol (pva) nano-fibers was compared with that of drug-loaded fabric (dlf) to be used in medical textiles and fibrous pads as a local drug delivery system. the drug-loaded nano-fibers (dlns) were coated on the fabric surface using the electro-spinning process. the dlf was then prepared by means of the pad-dry method. the characterization of the samples was carried out by sem, ftir, and xrd tests. uv-v is spectrophotometry was also used to measure the drug release rate. the anti-fungal effect was studied by the disk diffusion method. the drug release test showed about 75% fluconazole release in 90 min and the disc diffusion test indicated that the dlf has more effect than the dln due to the fast drug release.
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کلیدواژه
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nano-fibers ,candida albicans ,vulvovaginal candidiasis ,fluconazole ,drug delivery system
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آدرس
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isfahan university of technology, department of textile engineering, iran, isfahan university of technology, department of textile engineering, iran, isfahan university of technology, department of textile engineering, iran, isfahan university of medical sciences, school of medicine, department of parasitology and mycology, iran, isfahan university of medical sciences, school of medicine, department of parasitology and mycology, iran
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Authors
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