The Long-Term Prognosis of Posterior Urethral Valve in Neonate in North of Iran, a More than Ten Years’ Experience from a Tertiary Referral Center

Background and purpose: posterior urethral valve (puv) is one of the most severe urinarytract anomalies presenting as antenatal hydronephrosis that could lead to severe dilatation andfunctional impairment of one or both kidneys. the aim of this study was to analyze ourexperience on patients with a diagnosis of puv.materials and methods: in this prospective study neonates with a diagnosis of puv wereenrolled. the patients were assessed clinically for growth and hypertension and other clinicalcomplaints specially voiding dysfunctions. urinary tract ultrasonography study, functional renalscan, and voiding cystourethrography performed periodically. the patients were assessed foroccurrence of hypertension, growth disturbances, long term urinary tract dilatation, persistenceof vesicoureteral reflux (vur), recurrent urinary tract infection (uti), nephrolithiasis, voidingdysfunction, scar formation chronic renal failure (crf) and finally death.results: a total of 24 children with puv were enrolled, 18 (75%) had vur. the meanstandard deviation score for height to age was ?0.10. hydronephrosis was persisted in 22 (86%)of patients. vur was resolved in 9 (56%). uti was found in follow-up of 15 patients, 10 ofthem had recurrent episodes. nephrolithiasis was found in 8 (33%), persistent renal damage in14 (70%) and crf in 9 (37.5%) of patients, 5 of them had end-stage renal disease. voidingdysfunction was observed in 5 (36%) of patients, enuresis in 3 (21%) of them. two patientswere died in the course of disease.conclusion: puv is an important obstructive process with potential long-term complicationwith the need to assess the patients for long periods of time.