The relationship between Human Papillomavirus and Epstein-Barr virus infections with breast cancer of Iranian patients.

Background and aim: as the etiology and progression of breast cancer remainincompletely understood, novel routes of disease pathogenesis are important toconsider. some researchers have been found human papillomavirus (hpv) andepstein barr virus (ebv) in breast carcinomas (bcs).methods: paraffin-embedded sections from 65 female patients with breastcarcinoma and 53 breast tissues from patients with fibrocystic disease as controlwere selected. after dna extraction and amplification of housekeeping gene(beta-globin), all suitable samples were evaluated for presence of dna-ebv anddna-hpv by using pcr (polymerase chain reaction).results: hpv dna sequences were detected in 3 of the 53 benign breast tissuesamples but none of the breast carcinoma samples was identified. ebv wasdetected by pcr in 23 of 65 (35.38%) cases of breast cancer specimens and 11 of53 (20.75%) control samples (fibroadenoma 7 of 26 (26.92%) and fibrocystic 4 of27 (14.81%)). a total of 118 samples from 34 cases (81/28%) were positive.statistically, crammer indicator analysis for ebv infection in tumor samples andnormal samples was 0.46 which indicates a significant relationship.conclusion: our analysis could not confirm a role of hpv in breast cancer butstatistically, significant correlation between ebv infection and breast cancerexists. to demonstrate the possible relationship between viral load and breastcancer, need for epidemiological, biological and molecular mechanisms to clearthe virus is involved in the process of carcinogenesis.