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apatinib as a potential therapeutic agent in breast cancer treatment with a focus on clinical trials: a state-of-the-art study
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نویسنده
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naderi alizadeh mohammad ,rahimlou mohammad ehsan ,rahimlou elham ,vahedian vahid ,gharibi mahdi ,soltani nahal ,fathi maroufi nazila
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منبع
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research in molecular medicine - 2025 - دوره : 13 - شماره : 3 - صفحه:131 -142
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چکیده
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Breast cancer is the most common cancer in females. the treatment of this cancer is one of the challenges facing the world's health system. metastasis and cancer cell invasion are the reasons for the difficulty in treating this cancer. also, the formation of new blood vessels, or angiogenesis, facilitates metastasis in cancer patients. therefore, researchers are seeking new therapeutic drugs. one of the important factors in the processes of angiogenesis and metastasis is vascular endothelial growth factor and its receptor. agents that can inhibit this molecule and its receptor will have helpful therapeutic potential for treating breast cancer. apatinib is a drug that has drawn the attention of cancer researchers in the last decade, and many studies have been conducted on its effectiveness in cancer treatment, especially breast cancer. in this review article, we aimed to summarize the therapeutic potential of apatinib in vivo and animal models, with a focus on clinical trials.
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کلیدواژه
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apatinib ,breast cancer ,clinical trials ,metastasis
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آدرس
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shahid beheshti university of medical sciences, functional neurosurgey research center, shohada tajrish comprehensive neurosurgical center of excellence, iran, islamic azad university, marand branch, department of medical laboratory sciences, iran, islamic azad university, marand branch, department of medical laboratory sciences, iran, university of são paulo, faculty of medicine, clinical hospital, division of hematology and cellular therapy/lim-31, department of internal medicine, brazil. são paulo state cancer institute (icesp), comprehensive center for translational and precision oncology, brazil. hospital são luiz, institute of education and research, brazil, university of ankara, faculty of pharmacy, department of pharmacy, turkey, islamic azad university, marand branch, department of medical laboratory sciences, iran, university of ankara, faculty of pharmacy, department of pharmacy, turkey
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پست الکترونیکی
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n.fathi6788@gmail.com
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Authors
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