The Role of Moderate-intensity Continuous Exercise in Reducing Liver Enzyme Levels and Lipid Dysregulation in Platinol-induced Rats

Background: platinum-based chemotherapy, a cornerstone in cancer treatment, can induce hepatotoxicity. exercise can mitigate adverse effects of chemotherapy, including liver damage. this study aimed to investigate the protective effects of moderate-intensity continuous training (mict) on liver function and lipid metabolism in rats induced with platinol. materials and methods: twenty-four male sprague-dawley rats were randomly divided into four groups: a healthy control group, a platinol-injected control group, a mict group, and a platinolinjected group with mict. serum liver enzymes alkaline phosphatase (alp), alanine transaminase (alt), aspartate aminotransferase (ast) and lipid profiles were measured after 10 weeks of training or platinol injection. results: mict significantly reduced serum levels of ast, alt and alp in platinol-induced rats, comparable to healthy controls. additionally, mict improved lipid profiles by reducing cholesterol, triglycerides, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol (hdl). conclusion: mict may be a promising intervention to mitigate platinum-induced liver toxicity and dyslipidemia. further research is warranted to explore the potential clinical implications of these findings for cancer patients undergoing chemotherapy.