8-week aerobic exercise and vitamin d supplementation: impact on hypertension with vitamin d deficiency

Background: this research aims to investigate the performance of 8 weeks of aerobic exercise and vitamin d supplementation on nitric oxide (no) and endothelin 1 (et-1) indicators in patients with high blood pressure and vitamin d deficiency.materials and methods: in this quasi-experimental research, 40 qualified men and women were randomly divided into four groups (supplement group, placebo + exercise group, supplement + exercise group, and control group). the training program of the experimental groups included 8 weeks of aerobic exercise running on a treadmill (3 sessions per week). two groups (exercise + supplement and supplement group) received vitamin d supplement daily in the amount of 2000 international units in a double-blind manner, and the exercise + placebo group received a placebo capsule containing maltodextrin daily. blood sampling was done to evaluate biochemical variables 48 hours before and after the intervention in a fasting state.results: the research results show that after 8 weeks of aerobic training with vitamin d supplementation, there was no significant effect on body mass index, no, triglyceride (tg), total cholesterol (tc), high-density lipoprotein (hdl), low-density lipoprotein (ldl), vitamin d, and weight (p<0.05), but the effects were significant on et-1 level and systolic blood pressure which changed in the supplement, supplement+exercise, and exercise+placebo groups compared to the control group (p<0.05). also, the vitamin d increase showed a significant change (p<0.05).conclusion: based on the results of the present study, taking vitamin d supplements for 8 weeks along with aerobic activity reduces et-1, increases no, and improves blood pressure in hypertensive people with vitamin d deficiencies.