antibacterial effects of citrus aurantium on bacteria isolated from urinary tract infection

Background: emerging antibacterial resistance rates and beta-lactamase producing bacteria recovered from uti is an increasing problem in different regions, limiting therapeutic options. therefore, this study aimed at using the extract and essence of citrus aurantium (abundantly found in iran) and assessing their effect on bacterial agents causing urinary tract infections, and comparethe effect with common antibiotics used in treatment of uti. materials and methods: in an experimental design the e. coli, klebsiella pneumoniae, staphylococcus aureus, staphylococcus epidermidis, streptococcus agalactiae and enterococcus faecalis were isolated from uti and the antibacterial effect of citrus aurantium against this bacteria were determined using subculture. antibacterial effects of the herb extract were evaluated by well diffusion assay and nalidixic acid and co-trimoxazol were evaluated by agar disc diffusion. results: enterococcus faecalis showed 100% sensitivity to extract, essence and co-trimoxazole, and 80% to nalidixic acid. e. coli had 100% sensitivity to co-trimoxazole, and nalidixic acid and was totally resistant against extract and essence. klebsiella pneumonie had 80% sensitivity to co-trimoxazol, 75% to nalidixic acid and resistance against extract and essence. streptococcus agalactiae showed100% sensitivity to essence and co-trimoxazole and 90% sensitivity against nalidixic acid and shown 80% sensitivity to extract. staphylococcus aureus mrsa showed 100% sensitivity to co-trimoxazol and 70% sensitivity to essence, extract and nalidixic acid. conclusion: detection of antibiotic resistance among isolates is important in prevention and control of infections. in this study, the extracts of citrus aurantium were found with high antibacterial effects on gram positive bacteria compared with gram negative bacteria.