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effect of 8 weeks of aerobic training combined with vitamin d supplementation on nitric oxide and endothelin- 1 in patients with hypertension
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نویسنده
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jan faza mozaffar ,rahimi mohammad rahman ,afsargharehbagh roghaiyeh ,rostamzadeh nasser
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منبع
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research in molecular medicine - 2023 - دوره : 11 - شماره : 2 - صفحه:113 -120
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چکیده
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Background: this study aimed to investigate the effect of 8 weeks of aerobic exercise combined with vitamin d supplementation on nitric oxide (no) and endothelin-1 (et-1) in patients with hypertension.methods: in this quasi-experimental study, 40 eligible men and women with hypertension were randomly divided into four groups: supplement, placebo + exercise, supplement + exercise, and control. the training program included eight weeks of aerobic exercise running on a treadmill for 8 weeks, 3 sessions per week. the supplementation program included the intake of vitamin d supplements (2000 iu) daily in a double-blind manner. the placebo program was the intake of a capsule containing maltodextrin. blood sampling was taken to evaluate biochemical variables 48 hours before and after the intervention in a fasting state.results: after 8 weeks of aerobic exercise plus vitamin d supplementation, there was no significant effect on body mass index, no, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, vitamin d level, and weight (p>0.05). however, the et-1 level and systolic blood pressure were changed significantly in the supplement, supplement + exercise, and exercise + placebo groups compared to the control group (p<0.05).conclusion: eight weeks of vitamin d supplementation combined with aerobic exercise can reduce et-1 level and improves systolic blood pressure in people with hypertension.
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کلیدواژه
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vitamin d3 ,endothelin-1 ,aerobic exercise ,hypertension ,no
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آدرس
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university of kurdistan, faculty of humanities and social sciences, department of physical education, iran, university of kurdistan, faculty of humanities and social sciences, department of physical education, iran, urmia university of medical science, school of medicine, department of cardiology, iran, university of kurdistan, faculty of humanities and social sciences, department of physical education, iran
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پست الکترونیکی
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naserrostamzadeh806@gmail.com
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Authors
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