relationship of serotonin transporter gene polymorphism with temperament in persian medicine in fars province, iran

Background: despite its effectiveness, there are still many concerns and questions about theprinciples and therapeutic methods of traditional medicine (tm). in other words, to accept tm asa reliable healthcare system, modern scientific research should approve the principles of this system.temperament is one of the major determinants of persian medicine (pm), which is practicallyutilized to diagnose and cure diseases. considering the association of depression with the coldnesstemperament and the serotonin-tansporter-linked promoter region (5-httlpr) polymorphism, weproposed that the serotonin transporter gene could be one of the candidate genes contributing to thespecification of temperament. to test this hypothesis, we examined the association of 5-httlprpolymorphism with the hot/cold status of temperament in healthy individuals.materials and methods: the study included 351 healthy men (aged 20-40 years) referred to theorganization of blood transfusion in shiraz city, southern iran. the participants’ temperament (warm,temperate, and cold) was determined using a standard self-reported scale. then, we performedpolymerase chain reaction (pcr) to determine their 5-httlpr polymorphism genotype.multinomial logistic regression was used to evaluate a 95% ci and odds ratios for the association oftemperament with the 5-httlpr genotypes. statistical analysis was performed using the spss at asignificance level of less than 0.05.results: regarding the warm temperament, no association with the 5-httlpr genotypes wasobserved. however, regarding cold temperament, although our data showed no association with thess, the ls genotype showed some association. with reference to ll, the ls genotype decreased thepossibility of coldness rather than temperateness for the temperament (or=0.471, p=0.040).conclusion: our data revealed the association of temperament with the 5-httlpr polymorphism,suggesting that the serotonergic system may influence temperament. further studies are required toexplore the relation of genetic factors with temperament.