circulating mir-95 is a potential biomarker of chronic lymphocytic leukemia

Background: micrornas (mirnas) have crucial roles in cellular and molecular processes related to different malignancies including chronic lymphocytic leukemia (cll). studies revealed altered mir-95 expression in several diseases. long noncoding rnas (lncrnas) are a heterogeneous group of non-coding and regulatory rnas. the present study was conducted to investigate the association of mir-95 expression with cll by quantitative real-time pcr. materials and methods: sixty samples, including 30 cll and 30 healthy controls, were sampled during a period of 4 months. the expression of mir-95 was evaluated by quantitative real-time pcr in peripheral blood mononuclear cells from patients with cll and in healthy subjects. additionally, in silico pathway enrichment analysis was performed on validated and predicted targets of mir-95 in several databases, including mirecords and mirtarbase, while the interactions between predicted putative lncrnas and genes and mirna expression were examined with mirwalk. results: the expression of mir-95 was found to be significantly reduced in patients with cll compared to that in healthy controls ( p < 0.005). conclusion: mir-95 showed potential as a biomarker for the early diagnosis of patients with cll. lncrnas play a significant role in regulating cellular evolution, differentiation, and other processes and may be important regulators in tumorigenesis.