effect of foretinib on matrix metalloproteinase-2 (mmp2) expression in glioblastoma

Background: the most malignant form of infiltrating astrocytoma, glioblastoma multiforme (gbm), is one of the most aggressive human cancers. foretinib diminished gbm cell invasion by downregulating the expression of matrix metalloproteinase 2 (mmp2). the study aimed to examine the anti-tumor activity of foretinib and to test its effect on mmp2 expression in t98 cells. materials and methods: t98 cells were used as an experimental model of glioblastoma. the effect of foretinib on the expression of mmp2 was evaluated using quantitative real-time polymerase chain reaction. thereafter, the effect of foretinib on the enzyme levels of mmp was examined by zymography. statistical analyses were performed with graphpad prism software. results: a reduction in the expression of mmp2 was observed with an increase in the concentration of foretinib. conclusion: foretinib treatment leads to downregulation of mmp-2 and has a positive effect on t98 cells. we believe that foretinib can be subjected to further clinical investigation to develop a treatment for gbm.