combination effect of rotator cuff repair with secretome-hypoxia mscs ameliorates tnmd, runx2, and healing histology score in rotator cuff tear rats

Objectives: in order to treat a rat model of rotator cuff rupture, this work concentrated on the expression of tnmd and runx2, followed by rotator cuff repair and secretome-hmscs.methods: a total of thirty 10-weeks-old male sprague–dawley rats were separated into five groups randomly, rc on week 0, lesion treated with a rotator cuff repair and saline (rc + nacl group, n = 6) for 2 and 8 weeks, and lesion treated with a rotator cuff repair and secretome-hmscs (rc + secretome-hmsc group, n = 6) for 2 and 8 weeks. the supraspinatus and infraspinatus muscle–tendon units were obtained for histological and biomechanical investigation at 0, 2 and 8 weeks following injury.results: the findings showed that, in comparison with the rc + nacl group, secretome-hmscs significantly improved tendon repair by upregulating tnmd and runx2 expression and histology score.conclusion: combining secretome-hypoxia mscs with rc healing may help rats with rotator cuff tears.