The Effect of OnabotulinumtoxinA on the Symptoms and Quality of Life inWomen with Urge Urinary Incontinence

Objectives: to determine the effect of onabotulinumtoxina intradetrusor injection on quality of life (qol) and symptoms of women with urge urinary incontinence. methods: twenty five postmenopausal patients with urge urinary incontinence, underwent cystoscopy and 200 u onabotulinumtoxina intradetrusor injections (0.5 cc at each injection). the effects of botox have been evaluated on urge urinary incontinence and quality of life. results: the mean urge urinary incontinence per day was 7.25 which decreased to 2.87 (month 1) and 3.12 (month 6); p value = 0.019. the mean of nocturnal episodes was 3 which decreased to 0 and 1in the first and sixth months, respectively (p = 0.007). baseline mean i-qol total score was 43.37 which reached 82.12 (month 1) and 78.87 (month 6); p < 0.001. conclusions: onabotulinumtoxina significantly decreased urinary urge incontinence and nocturia at month 1 and 6. the quality of life of patients has improved.