effect of nandrolone treatment with and without resistance training on superoxide dismutase concentration and pathology of kidney tissue in rats

Background: the prevalence of anabolic steroids abuse in athletes and non-athletes is associated with the risk of injury to various organs, but there are limited studies of oxidative changes in kidney tissue following nandrolone (n) administration. objectives: the aim of this studywasto investigate the effect of n treatment with and without resistance training (rt) on superoxide dismutase (sod) concentration and tissue pathology of kidney tissue in rats. methods: in this experimental study, 20 male wistar rats were randomly divided into four groups of five rats including 1) control (c), 2) sham (normal saline) (sh), 3) n, and 4) n + rt. groups 3 and 4 received 10 mg/kg n peritoneally, and the n + rt group performed 1 m ladder climbing for eight weeks and three sessions per week. sod levels of kidney tissue were measured by elisa and radioimmunoassay. hematoxylin-eosin (h&e) staining was used to evaluate oxidative stress levels in kidney tissue. one-way anova with bonferroni’s post- hoc tests were used for analysis of research findings in spss version 22 (p≤0.05). results: sod levels in the c group were higher than the sh (p = 0.001), n (p = 0.001), and n + rt (p = 0.001) groups. sod levels were lower in the sh group than in the n (p = 0.049) and n + rt (p = 0.001) groups. however, there was no significant difference in sod levels in the n + rt group and n group (p = 0.28). also, oxidative stress levels were normal in tissue studies in all groups. conclusions: it seems that n treatment with and without rt reduces sod activity in kidney tissue, but more studies are needed in this regard given the normality of tissue oxidative stress results.