the effect of aerobic training with vitamin c supplementation on myeloperoxidase, asymmetric dimethyl arginine and blood pressure in middle-age hypertensive overweight men

Background: cardiovascular diseases such as hypertension are global health concerns. objectives: the purpose of this study was the effect of intensive aerobic training with vitamin c supplementation on myeloperoxidase (mpo), asymmetric dimethyl arginine (adma), and blood pressure (bp) in hypertensive men. methods: forty hypertensive men (age: 44.6±3.5 y, body mass index: 28.2±1.2 kg.m^-2) volunteered to participate in this study and were randomly divided into four groups of aerobic training with vitamin c (atv;n= 10), aerobic training with placebo (atp;n= 10), vitamin c group (vc; n = 10) and control (con; n = 10). the exercise training consisted of running training, which was done three times a week for 10 weeks, with the intensity of 75% - 85% hr max, and the duration of 20 - 45 minutes. atp and vc groups consumed daily 500mgof vitamin c or placebo. fasting blood samples were measured before the start training protocol and 24 hour after last training sessions to measure mpo and adma in the serum. results: the results of present studyshowedthatadmaandbp were significantly decreased only inatvandatp (p>0.05). however, mpo did not change significantly (p > 0.05). also, were seen that no significant difference between atv and atp groups (p > 0.05). conclusions: it can be concluded that, aerobic training caused to decrease of dimethyl arginine, that can be a good strategy for control or decrease of blood pressure in hypertensive subjects, however intensive aerobic training with vitamin c may have better efficacy.