Interventional Closure of Patent Foramen Ovale (PFO) with Amplatzer PFO Occluder in Patients with Paradoxical Cerebral Embolism

Background: percutaneous transcatheter closure has been proposed as an alternative to surgical closure or long-term anticoagulation in patients with presumed paradoxical embolism and patent foramen ovale (pfo).methods: there were two symptomatic patients (29 and 47 years old) who underwent percutaneous transcatheter closure of pfo after at least two events of cerebral ischemia; one embolic event had occurred under anti-platelet therapy. for both patients, amplatzer pfo occluder measuring 25 mm in diameter were used. in both cases, complete occlusion by color dop-pler and transesophageal contrast echocardiography investigation was achieved after the procedure and lasted at least up to 3 months after implantation as determined by our follow up. mean fiuoroscopy time was 16.7 minutes.results: percutaneous transcatheter closure was technically successful in both patients (100%). no residual shunt was seen at the end of the procedure or in follow-ups. in-hospital follow-up was uneventful. at a mean follow-up of 3 months, no recurrent embolic neurological events were observed.conclusion: transcatheter closure of pfo with amplatzer pfo occluder devices is a safe and effective therapy for patients with previous paradoxical embolism pfo. percutaneous closure is associated with a high success rate, low incidence of hospital complications, and freedom of cerebral ischemic events.