Mean Platelet Volume asa Predictorof One-Year Major Adverse Cardiac Events followingElective Percutaneous Coronary Interventions

Background: mean platelet volume (mpv) correlates with platelet activity.the relation between mpv and long-term outcome in patients undergoing percutaneous coronary intervention (pci) has been investigated in several studies.the aim ofthe present study was to investigate the utility of mpv in prognosticatingthe long-term outcome after elective pci.methods:the study cohort included2627 patients undergoing electivepci between september 2008 and june 2010,whose baseline mpv measurements before pci were available. the patients were divided into three groups of mpv < 9.1 fl, mpv = 9.1 to 10 fl, and mpv > 10 fl, and they were assessed for developing major adverse cardiac events (mace), comprising death, myocardial infarction (mi), target vessel revascularization (tvr), and target lesion revascularization (tlr) over a one-year follow-up.results:of 2539 patients, major adverse cardiac events (mace) at one year occurred in 77 (3.0%) patients, including mortality in 26 (1.0%). the patients in the highest tertile (mpv > 10fl) had no increasedfrequency of mace compared to those in the mid (9.1 to 10fl) and lowest( < 9.1 fl) tertiles (3.3%, 2.2%, and 3.8%, respectively; p value =0.14). no significant differences were found for each of the primary endpoints among the mpv tertiles. in multivariate logistic regression, we investigated the association between high mpv and total mace (or=1.10, 95%ci: 0.69-1.77;p value = 0.68), death (or=1.14,95%ci: 0.51-2.54;p value = 0.74), and non-fatal mi (or=1.85, 95%ci: 0.73-4.67;p value =0.19) at oneyear's follow-up but mpv did not remain in the model in any of the cases.in the diabetic patients, the one-way analysis of variance demonstrated that mortality was 1.6% (4 patients) in the highest tertile, 0.8% (2 patients) in the mid tertile, and 0.5% (one patient) in the lowest tertile.conclusion: there was no direct correlation between pre-proceduralmpv and mace in elective pci. mpv can only be considered as an appropriate factor for predicting mortality in diabetic patients undergoing elective pci.