the effects of albumin 20% and hydroxyethyl starch 6% on bleeding and interleukin-6 levels as priming solutions for cardiopulmonary bypass: a randomized controlled trial

Background: cardiopulmonary bypass (cpb) can adversely affect coagulation and systemic inflammatory response. given that the optimal strategy for priming cpb in cardiac surgery remains a matter of debate, this study aimed to investigate the effects of albumin 20% and hydroxyethyl starch 6% as priming solutions on bleeding and interleukin-6 (il-6) levels during cpb.methods: this randomized clinical trial involved 40 patients undergoing coronary artery bypass surgery at shahid chamran hospital between july 2021 and july 2022. participants were assigned to 2 groups: the first group received 50 ml of albumin 20% as the priming solution for the cpb circuit, while the second group received 500 ml of hydroxyethyl starch 6%. bleeding and il-6 levels were assessed before and after the intervention.results: the albumin group comprised 80.0% men and 20.0% women, with a mean age of 66.45±5.84 years. the hydroxyethyl starch 6% group consisted of 85.0% men and 15.0% women, with a mean age of 63.05±5.92 years (p>0.05). the findings revealed that 12 hours after cpb, the il-6 level in the hydroxyethyl starch 6% group (mean: 171.6±77.71 pg/ml) was significantly higher than that in the albumin group (mean: 105.8±36.45 pg/ml; p=0.002). at 48 hours after cpb, the mean bleeding was not significantly different between the groups (p=0.950).conclusion: albumin 20% was more effective than hydroxyethyl starch 6% concerning il-6 levels. however, no significant differences in bleeding were observed between the groups at 48 hours post-cpb.