association between cardiovascular risk factors and high-risk features in myocardial perfusion imaging: a multicenter study

Background: myocardial perfusion imaging (mpi) is a noninvasive method with acceptable sensitivity and specificity in diagnosing coronary artery disease (cad) in moderate-risk patients, including those with cad risk factors. methods: the present cross-sectional, prospective study was conducted on 4886 patients from april 2020 through march 2023 at chamran and tehran heart center hospitals. a questionnaire regarding anthropometric variables, demographic characteristics, cad risk factors, and mpi findings was designed. results: totally, 2179 patients (44.6%) had abnormal mpi. patients with abnormal mpi were significantly older than those with normal mpi. older age (or, 1.64; 95% ci, 1.2 to 1.72; p<0.001), diabetes mellitus (dm) (or, 1.36; 95% ci, 1.1 to 1.48; p=0.012), hypertension (or, 1.24; 95% ci, 1.04 to 1.37; p=0.032), and dyslipidemia (or, 1.54; 95% ci, 1.25 to 1.8; p<0.001) were associated with abnormal mpi independently. patients with more cad risk factors were more likely to have abnormal mpi. thus, in patients without or at most with 1 risk factor and those with 8 cad risk factors, the likelihood of abnormal mpi was 3.7% and 76.2%, respectively. the frequency of left ventricular dilation and right ventricular prominence was significantly higher in patients with older age (p<0.001 and p=0.043, respectively), dyslipidemia (p<0.001 and p=0.007, respectively), dm (p<0.001 and p<0.001, respectively), and hypertension (p=0.048 and p=0.057, respectively). conclusion: individuals with cad risk factors, especially those with older age, dm, hypertension, or dyslipidemia, require meticulous attention during cad evaluation, particularly via mpi.