In-Hospital Outcome of Patients with Diabetes Mellitus after CTO Recanalization with Third Generation Drug-Eluting Stents

Background: percutaneous coronary intervention (pci) of total chronic coronary occlusions (ctos) still remains a major challenge in interventional cardiology. there is little knowledge in the literature about differences in cto-pci between diabetic and nondiabetic patients in the era of third-generation drug-eluting stents (dess). in this study, we analyzed the impact of diabetes mellitus (dm) on procedural characteristics, complications, and acute outcomes in a cohort of 440 patients. methods: between 2012 and 2016, we recruited 440 consecutive patients, 116 of them with dm. all the patients underwent pci for at least 1 cto. antegrade and retrograde cto recanalization techniques were applied. only third-generation dess were used. we used t-tests and the pearson chi-quadrat test to test the significant differences in the variables between the 2 groups. results: the patients with dm were older than the nondiabetics (64.5 y vs. 61.1 y; p=0.003), and they suffered more frequently from a chronic kidney disease (7.1% vs. 2.4%; p=0.001). the nondiabetics less frequently had arterial hypertension (75.3% vs. 89.7%; p=0.001); however, they more often had a family liability for cad (32.1% vs. 22.4%; p=0.050) and had a higher left ventricular ejection fraction (59.2% vs. 56.7%; p=0.011). the success rate was 85.2% in the patients without dm and 81.2% in the patients with dm (p=0.403). the existence of dm had no impact on the procedural success and complication rates. conclusion: our study on 440 patients shows that diabetics and nondiabetics have similar success and complication rates after the recanalization of ctos using third-generation dess. it is a feasible and safe procedure and can be recommended as an alternative treatment.