Association between Serum Kalirin Levels and the KALRN gene rs9289231 Polymorphism in Early-Onset Coronary Artery Diseas

Background: recently, rs9289231 genetic variations of kalirin (kalrn) have been introduced as potential genetic markers for coronary artery disease (cad). however, the influence of kalrn single-nucleotide polymorphisms (snps) on serum kalirin levels has not been investigated in cad patients so far. thus, the present study aimed to survey whether snp t > g (rs9289231) was associated with the risk of early-onset cad and serum kalirin levels among the study subjects. methods: the rs9289231 polymorphism of the kalrn was genotyped in 512 subjects (61.5% male, mean age = 46.3 ± 7.1 y), comprising 268 subjects with angiographically diagnosed cad and 244 controls using an hrm assay. also, the levels of serum kalirin were compared between 133 cad subjects and 123 controls using a sandwich elisa assay. results: the cad subjects had more frequently gg genotypes than the controls. the odds ratio (or) remained significant after adjustment for known cad risk factors (or = 4.13, 95% ci: 2.48–9.10; p value < 0.001). a significant difference was also observed in that the g allele was more frequent among the cad subjects. the g allele at the rs9289231 polymorphism was associated with a higher risk of cad (or = 2.11, 95% ci: 1.27–2.59; p value = 0.001). the mean kalirin level of the cad patients was higher than that of the controls (p value = 0.041). no significant correlation was seen in the different genotypes with serum kalirin levels. conclusion: the kalrn rs9289231 t > g variant was considerably related with an increased risk of early-onset cad. high kalirin levels were found in young cad patients compared to the control subjects, with the levels not affected by the different genotypes of rs9289231.