Nobel Prize in Physiology or Medicine for the Year 2007: Breakthrough in Pathophysiology and Experimental Therapy of Cardiovascular and Other Diseases

In the year 2007, professor of human genetics and biology mario capecchi from university of utah, usa, professor of mammalian genetics martin j. evans from school of biosciences, cardiff university, wales, uk, and professor of pathology and laboratory medicine oliver smithies from university of north carolina, usa shared the nobel prize in physiology or medicine for developing a way to eliminate or knockout specific genes in mice.1,2 joint efforts of these distinguished scientists allowed the creation of a variety of animal models to study pathophysiology and experimental therapy of mono- and polygenic human diseases, including cardiovascular diseases.