Association between the hepatic lipase promoter region polymorphism (-514 C/T) and the presence and severity of premature coronary artery disease

Background: hepatic lipase (hl) plays a crucial role in lipid metabolism,but there is debate about whether hl acts in a more pro-or more anti-atherogenic fashion. we aimed to examine the relationship between the-514 c/t polymorphism within the hl gene (lipc) and the risk of angiographically determined premature coronary artery disease (cad). methods: four hundred seventy-one patients with newly diagnosed angiographically documented (≥ 50% luminal stenosis of any coronary vessel) premature cad were compared to 503 controls (subjects with no luminal stenosis in coronary arteries). a real-time polymerase chain reaction and high-resolution melting analysis was used to distinguish between the genotypes. results: there was no significant difference in the distribution of-514 c/t genotypes between the 2 groups in the whole population or in the men,but the examined polymorphism was found to be associated with the presence of cad in the women (p value = 0.029). after the application of a multiple logistic regression model,the minor t allele of the lipc gene was not found to be independently associated with the presence of cad either in the total population (adjusted or = 0.97,95% ci = 0.75-1.25; p value = 0.807) or in the women (adjusted or = 0.91,95% ci = 0.59-1.40; p value = 0.650) and in the men (adjusted or = 1.15,95% ci = 0.81-1.64; p value = 0.437) separately. conclusion: our findings suggest that there is no relationship between the lipc-514 c/t and the risk of premature cad or its severity in patients undergoing coronary angiography. © 2017,tehran heart center. all rights reserved.