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Relation between intersection of nullclines and periodic solutions in a differential equations of p53 oscillator
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نویسنده
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Rangi F ,Tavakoli M
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منبع
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iranian journal of numerical analysis and optimization - 2013 - دوره : 3 - شماره : 2 - صفحه:67 -77
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چکیده
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We consider a simple mathematical model that suggests emergence of oscillations in p53 and mdm2 protein levels in response to stress signal. intracellular activity of the p53 protein is regulated by a transcriptional target, mdm2, through a feedback loop. the model is classified in five cases with respect to intersection of nullclines. in each case occurrence(or not) of the limit cycle is investigated.
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کلیدواژه
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DNA damage ,p53-Mdm2 ,Limit cycle ,Mathematical biology
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آدرس
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دانشگاه فردوسی مشهد, دانشجو, ایران, دانشگاه فرهنگیان, دانشجو, ایران
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پست الکترونیکی
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tavakoli@gmail.com
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Authors
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