Roles of Serum Parathyroid Hormone and Vitamin D Levels in Severity of Coronary Artery Disease and Left Ventricular Systolic Function

Background: vitamin d and parathyroid hormone (pth) are related but impact cardiovascular functions differently. objectives: this study investigated the roles of pth and vitamin d serum levels in the severity of coronary artery disease and left ventricular systolic function (lvsf). methods: this cross-sectional study was conducted on 271 participants who underwent elective coronary angiography at dr. heshmat hospital, selected by convenience sampling over four months. 25-hydroxyvitamin d (25 (oh) d) and pth levels were obtained from patients’ blood samples. vitamin d levels were categorized into three categories. the syntax score was used to evaluate the severity of coronary artery disease (cad), classified across three categories. the chi-squared test, independent samples t-test, and multivariable logistic regression were used for statistical analysis. data were analyzed by spss ver.21. results: diabetes, hypertension, dyslipidemia, and lower vitamin d levels were independent variables affecting patients’ high-risk conditions. the highest syntax score was in patients with vitamin d deficiency (p < 0.001). patients with different ejection fractions did not have statistically significant differences in vitamin d (25.38 ± 14.23) and pth levels (66.62 ± 17.39) (p = 0.4). the severity of cad in patients with pth > 40 was higher than in patients with pth ≤ 40, but this was not statistically significant (p = 0.06). conclusion: our results showed an inverse relation between cad and vitamin d. however, the cad risk did not change with pth levels.