Effect of Colloid versus Crystalloid Administration of Cardiopulmonary Bypass Prime Solution on Tissue and Organ Perfusion

We evaluated the effects of tissue and organ perfusion during and after coronary artery bypass graft surgery with either colloid (voluven) or crystalloid (lactated ringer’s) as prime solution. methods: in this prospective randomized-controlled trial study, 70 patients undergoing on-pump coronary ar- tery bypass graft surgery were randomly assigned to receive either colloid (voluven) or crystalloid (lactated ringer’s) as prime solution, for initiation of cardiopulmonary bypass machine procedure. tissue and organ perfu- sion markers including lactate, troponin i, liver and renal function tests and electrolytes were measured sequen- tially, before induction (t1) to second days after surgery (t5). results: with exception of chloride and potassium levels no significant differences detected in other measure- ments, and the laboratory results were entirely identical in both procedures. conclusion: there was no significant difference between voluven® ( hydroxyethyl starch, hes 130/0.4) and crystalloid (lactated ringer’s) as priming solution on the basis of organ and tissue perfusion tests assessment.