Tris (2aminoethyl) Amine Functionalized Nanoporous Silica Sba15 As A Potential Drug Carrier For Citalopram

Introduction: ordered nanoporous silica such as sba15 has a great potential for application in controlled drug release systems. chemical modification of the silanol groups of sba15 allows better control over drug loading and release. therefore, tris(2aminoethyl) aminefunctionalized mesoporous silica sba15 was evaluated as a potential carrier for the delivery of citalopram. methods: tris (2aminoethyl) aminefunctionalized sba15 was synthesized and characterized by various methods. citalopram was loaded on the functionalized sba15 and drug release into simulated body fluid (sbf) solution and phosphate buffers was investigated. results: the optimal condition for loading of the citalopram was obtained at ph = 9 after stirring for 5 minutes. the release profile of citalopram was monitored in phosphate buffers with three different ph values of 5, 7, and 8. a faster release rate at lower ph value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized sba15. the average release rate of citalopram from each gram of functionalized sba15 was 12 µg h1 in the sbf. conclusion: the results showed that loading amount and release rate of citalopram depended on ph value and the release process showed a very slow release pattern. therefore, tris (2aminoethyl) aminefunctionalized sba15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.