Comparison the Effects of Trigonella Foenum-Graecum L. Seed and Cordia Myxa Fruit Extracts on Diabetes-Induced Memory Impairment in Rats

Introduction: trigonella foenum-graecum l. (fenugreek) seeds and cordia myxa fruits have been known as agents with anti-diabetes effects in iranian traditional medicine. we compared the effects of aqueous extracts of these plants on diabetes-induced cognitive dysfunction. methods: in our study, rats were equally allocated to 4 groups (n = 12/group) as follows: control; diabetic; diabetic rats treated with t. foenum graecum seeds extract (te) (870 mg/kg bw); and diabetic rats treated with c. myxa fruit extract (ce) (500 mg/kg bw) for 30 days. diabetes was induced by alloxan (120 mg/kg bw, ip). cognitive dysfunction was determined through memory task and passive avoidance learning (pal). results: diabetes resulted in cognitive impairment in pal and memory task. ce and te significantly reduced serum blood sugar (p < 0.05) and brain lipid peroxidation (p < 0.001). moreover, treatment with both extracts prohibited learning and memory deficits in diabetic groups in comparison to the non-treated group; however, there was no significant difference between the groups that were treated with te or ce. conclusion: aqueous extract of fenugreek seeds and c. myxa are effective in preventing diabetesinduced lipid peroxidation and memory loss in animal models of diabetes.