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Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
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نویسنده
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mojtahedi zahra ,rezaeifard somayeh ,faghih zahra
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منبع
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iranian journal of colorectal research - 2016 - دوره : 4 - شماره : 4 - صفحه:1 -7
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چکیده
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Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on its content. the composition of microbiota critically determines the differentiation, activation, and expansion of t cells by which pro- or anti-tumorigenic effects of microbes are frequently reported to be mediated. in this review study, we specified an imbalance in microbiota and t cells in particular regulatory t cells and th17 cells in colon cancer. we also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing t cells.
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کلیدواژه
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Colon Cancer ,Microbiota ,T Cells ,Tregs ,Th17
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آدرس
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shiraz university of medical sciences, shiraz institute for cancer research, school of medicine, ایران, shiraz university of medical sciences, shiraz institute for cancer research, school of medicine, ایران, shiraz university of medical sciences, shiraz institute for cancer research, school of medicine, ایران
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پست الکترونیکی
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faghihz@sums.ac.ir
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Authors
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