the effect of asacol (mesalazine) suppository on the healing of acute fissures caused by diarrhea: a randomized controlled trial

Background: an anal fissure is a linear, superficial tear in the squamous epithelium of the anus, specifically inthe anoderm distal to the dentate line. given the well-established anti-inflammatory properties of mesalazine inacute conditions, it helps prevent secondary stricture and reduces the risk of complications such as incontinencethat may arise during fissure surgery. this study investigates the effect of asacol (mesalazine) suppositories inthe treatment of acute anal fissures caused by diarrhea, compared to a placebo.methods: this double-blind, randomized controlled clinical trial involved 69 patients aged 18 to 65 yearswho experienced diarrhea followed by acute fissure symptoms lasting less than six weeks. participants wererandomly assigned and blinded into two groups: 34 in the control group and 35 in the treatment group. bothgroups applied diltiazem ointment three times daily and took hot water basin baths twice daily. the controlgroup received a placebo, while the treatment group was administered asacol suppositories. the primaryoutcome measures were the degree of pain reduction and the speed of recovery.results: the findings indicated that the recovery rate in the experimental group (80%) was significantly higherthan in the control group (38.2%) (p<0.001). the current study also investigated the consumption of coffee andthe incidence of anal fissures, revealing that the likelihood of recovery was not associated with tea or coffeeconsumption. additionally, patient age showed no significant relationship with the chance of recovery; themean age of the study population was 43.49±15.08 years.conclusion: the findings of the current study indicate that asacol suppositories have a significant effect on thehealing of acute anal fissures caused by diarrhea and can be considered a viable treatment option.