novel molecular prognostic and diagnostic techniques in colorectal cancer

Background: colorectal cancer (crc) is a prominent cause of malignancy-associated death worldwide. this disease is predominantly symptomless as it advances to the highest stages, meaning that screening schemes aimed at early diagnosis are required to lower the prevalence and fatality rate. we aimed to review the literature on different molecular procedures for detecting stool-based biomarkers of crc. methods and evidence acquisition: we reviewed papers from google scholar and pubmed on different molecular procedures for detecting stool-based biomarkers of crc with no time limitation. conclusion: an integrative framework of all epigenetic and genetic modifications was studied, representing more acceptable specificity and sensitivity for the diagnosis, treatment, and drug response/outcome evaluation of crc compared to other traditional procedures. differential expression analysis of stool-derived rna (srna) and stool dna (sdna) testing for ultrasensitive mutations, methylation, and fragmentation patterns can lead to an accurate, early-stage diagnosis and a better prognosis for crc patients.