First Degree Relatives of Bangladeshi Prediabetic Subjects are at Increased Risk for Developing Glucose Intolerance

Background: the racial variation in genetic susceptibility of type2 diabetes mellitus is well established. the stages of impaired fasting glucose (ifg) and/or impaired glucose tolerance (igt) (collectively known as ‘prediabetic stages) are combined to be intermediate in the natural history of diabetes, but their genetic susceptibility are still a matter of investigation. family study is the primary step to explore genetic susceptibility. in particular, there has been no study in bangladesh related to genetics of prediabetes. objectives: the present study aimed to explore the genetic susceptibility of prediabetes in bangladeshi population by observing the clustering of dysglycemia in first degree relatives of prediabetes. methodology: the study was designed as an experimental group comparison study. newly detected prediabetic subjects (isolated ifg, igt, ifg+igt) were collected from birdem opd and reconfirmed by ogtt following who guidelines and sub grouped. relatives of the prediabetes, up to first generation, were included as cases and termed as r-ifg (first degree relatives of ifg), r-igt (first degree relatives of igt), r-ifg-igt (first degree relatives of ifg-igt) corresponding to the subgroups of prediabetes. each relative underwent an ogtt following the same guideline. blood glucose was measured by glucose oxidase method. results: different types of prediabetic subjects (ifg, igt, ifg+igt) and their first degree relatives (r_ifg, r_igt, r_ifg+igt) were studied. among 41 first degree relatives of ifg (r_ifg), 2 (4.9%) had ifg, 4 (9.8%) had igt, 1 (2.4%) had combined ifg+igt, 5 (12.5%) had t2 dm and 29 (70.7%) had normoglycemia. among 116 first degree relatives of igt (r_igt) none (0.00%) had ifg, 15 (12.9%) had igt, 2 (1.7%) had combined ifg+igt, 22 (19%) had diabetes and 77 (66.4%) having absolutely normal ogtt reports. among 76 first degree relatives of ifg+igt (r_ifg+igt), 2 (2.6%) had ifg, 4 (5.3%) had igt, 1 (1.3%) had combined ifg+igt, 19 (25%) had diabetes and 50 (65.8%) were normoglycemic. conclusion: clustering of pre-diabetes and diabetes is present in families of prediabetic subjects and they should be taken as a major target for primary prevention of these disorders.