the lipid profile parameter in chronic obstructive pulmonary disease patients and correlation with severity of disease

Introduction: more than 90% of the deaths caused by chronic obstructive pulmonary disease (copd) occur in the low- and middle -income countries. the main aim of this study was to investigate the lipid profile levels in copd patients and examine the correlation of total cholesterol, triglycerides, low-density lipoproteins, high density lipoproteins, and ldl/hdl risk ratio with copd stages that are developed by the global initiative for chronic obstructive lung disease (gold) materials & methods: a total of 100 copd patients including 25 copd non-smokers were enrolled in this study. the diagnosis of copd was carried out by using the spirometry following the gold guidelines (post-bronchodilator forced expiratory volume (fev1)/forced vital capacity (fvc) ratio < 70% predicted). accordingly, the patients were divided into four groups based on the severity of their disease in accordance with the gold guidelines, including mild copd (stage i, fev1 ≥ 80% predicted), moderate copd (stage ii, 50% ≤ fev1 < 80% predicted), severe copd (stage iii, 30% ≤ fev1 < 50% predicted), and very severe copd (stage iv, fev1 < 30% predicted). the fasting blood samples of lipid profile were collected. the four copd groups were compared using the anova test. results: according to the results, the majority 53 patients (53%) were in age group 40 to 60 years with mean age of 60.46 +/-11.56. most of the patients had moderate to severe airflow obstruction (gold stages ii and iii). the severity of copd had no significant correlation with the triglycerides, ldl, hdl, and ldl/hdl risk ratio. the mean total cholesterol levels in the stages i and iv were 151.92±32.82 and 128.50 ±21.46 mg/dl, respectively, which was statistically significant (p=0.04). conclusion: the present study indicates that there was no significant correlation between various lipid profile parameters and severity of copd.